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RAD-140 is a relatively new SARM to hit the scene and it was designed with one overarching goal in mind.

To Act As A Complete Replacement For Testosterone, Without Any Of The Negative Side Effects.

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RAD-140 is a selective androgen receptor modulator (SARM) and has been studied and proven to improve lean body mass and physical function. It also increases tendon strength, ligament health, bone density and encourages collagen turnover.

It is non-steroidal and has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic effects that come from anabolic androgenic steroids (AAS).

In addition, it is touted as a “replacement” for hormone replacement therapy.

Essentially, it is being labeled by many as the safe non-steroidal version of testosterone, which is injection free and poses none of the negative side effects.

Yes, kind of…

Let me elaborate on that for you:

Rad-140 in particular has an anabolic:androgenic rating of 90:1 and partially antagonizes the negative effects of testosterone on the prostate.

The anabolic:androgenic ratio is essentially a ratio which exhibits how much anabolic activity a specific compound will exert in the body, and how much androgenic activity it will exert in the body.

Anabolic, meaning that they promote anabolism (cell growth), and Androgenic (or virilising), meaning that they affect the development and maintenance of masculine characteristics.

The androgenic:anabolic ratio of a compound is a very important factor when determining the clinical application of it.

Initial steroid research sought to synthesize a compound which retained a high degree of anabolic activity, coupled with a diminished androgenic activity, the goal being to produce a compound with a high anabolic yet low androgenic effect.

Because steroids were intended for medical treatment, patients could include men and women, and even children.

The last thing you want to do is give a girl a bunch of testosterone so she can prevent muscle wasting, only to have her end up with a butt load of masculinizing side effects like the deepening of her voice, acne, clitoral enlargement, body hair growth, and all the other fun things that come along with anabolic androgenic steroids.

The androgenic side effects of steroids in men aren’t fun either. The risk of Gynecomastia (man boobs), endocrine shutdown (infertility), testicle shrinkage, negative effects on cholesterol, increased risk of heart disease, among many other side effects are all very real side effects of anabolic androgenic steroids.

I’m not saying that these will happen for sure at all, but there is a chance of them occurring with its’ use.

Considering this, it is obviously very important to avoid any androgenic effects when providing anabolic treatment to patients.

Compounds with a high ratio of androgenic to anabolic effects are the drug of choice in androgen-replacement therapy, whereas compounds with a reduced androgenic:anabolic ratio are preferred for anemia, osteoporosis, and to reverse protein loss following trauma, surgery or prolonged immobilization (the type we want).

So how this all relates to RAD-140’s 90:1 anabolic:androgenic ratio is that:

RAD-140 could be used in a complete absence of testosterone and still exert just as much anabolic activity in muscle and bone as testosterone would, while exerting none of testosterone’s negative side effects.

This would consequently eliminate and replace the need for testosterone use.

In addition, RAD-140 not only synergistically works alongside testosterone to potentiate it’s functions if they were run in unison, but it would offset testosterone’s negative side effects like the negative side effects it can have on the prostate.

This is debatable as different SARMs act on the androgen receptor in different ways and accomplish different things.

It is undeniable the RAD-140 is indeed very strong though, and pound for pound it is one of the strongest SARMs on paper with a 90:1 anabolic:androgenic ratio.

It is formidable to the strength of LGD-4033 on a muscle building and body recomposition scale.

Strength gains are only slightly less impressive than S4, but it doesn’t cause the temporary potential night vision blindness side effect that we all know and hate that dosing S4 on the high end of the spectrum can cause.

It’s ability to increase endurance and speed is the strongest of all SARMs (no Cardarine technically isn’t a SARM).

Basically, RAD-140 is a great hybrid SARM that is great in essentially every aspect, most specifically being adding energy, strength and size.

RAD-140 doesn’t require any injections as it has a high level of oral bioavailability

Only one dose is needed per day to reap ALL the benefits RAD has to offer, while synthetic testosterone injections need to be pinned a couple times per week minimum to maintain stable hormone levels in the blood, which can be a nuisance, not to mention extremely inconvenient if you are traveling (good luck bringing your testosterone from your local underground juice dealer across the border or on a plane).

If you don’t have a prescription for testosterone, forget about bringing it anywhere where inspections will be taking place or you may quickly find yourself in a very unpleasant situation.

This is where RAD-140 shines. Not only in convenience, but in its’ ability to produce worthy gains formidable to that of testosterone.

Allow me to list JUST SOME of the many benefits of RAD-140:

– Replicates the benefits of Testosterone without the negative side effects

– Doesn’t require any injections

– Doesn’t convert aromatize into estrogen at all

– Can build muscle while simultaneously burning fat

– Endurance, stamina and speed are all greatly enhanced (the only compound better than RAD-140 for endurance is Cardarine)

– Dramatic increases in nitrogen retention result in great muscular fullness

– Big increases of strength comparable to LGD-4033 and S4

– Clinical studies have shown NO side effects to date

After ingestion, RAD-140 will begin to spool up in your blood and exert several positive benefits.

While all SARMs to some degree help with stamina, RAD-140 in particular is exceptional in regard to its’ ability to increase endurance (cardiovascular and muscular endurance), stamina, and speed.

RAD-140 is only second to Cardarine in its’ ability to crank endurance through the roof.

A high intensity cardio session that would normally make you want to kill yourself and being gasping for breath could seem like a cake walk on RAD-140.

In addition, RAD-140 exhibits fantastic increases in muscular volume, overall fullness, post cycle treatment nolvadex for gynecomastia vascularity, and strength.

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With an anabolic:androgenic ratio of 90:1, over the course of a RAD-140 cycle it can be expected to make gains formidable to that of hormone replacement therapy doses of pharmacy grade testosterone, without any of the negative side effects associated with steroid use, or anything for that matter as clinical trials have yet to find one single negative side effect from RAD-140.

There are several readily available studies demonstrating how effective RAD-140 is. For your reference, here are just a few of them:

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140

Results: “Taken in sum, RAD140 has all the hallmarks of a SARM. It is potency selective, since it stimulates muscle weight increases at a lower dose than that required to stimulate prostate weight increases. Moreover, it is also efficacy selective, because it is fully anabolic on muscle but demonstrates less than complete efficacy on the prostate and seminal vesicles and, in fact, can partially antagonize the stimulation of the seminal vesicles induced by testosterone. RAD140 has excellent pharmacokinetics and is a potent anabolic in nonhuman primates as well. We believe the overall preclinical profile of RAD140 is very good, and the compound has completed preclinical toxicology in both rats and monkeys.”

Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.

Results: “In cultured hippocampal neurons, RAD140 was as effective as testosterone in reducing cell death induced by apoptotic insults.”

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140

Results: Mean weight gain of greater than 10% in only 28 days of dosing was achieved at a dose of just 0.1 mg/kg.

I actually found this was a decently “wet” compound.

Despite it being purported as dry gains by some, I seemed to gain weight pretty quickly from it. Some of it being water.

Now this isn’t necessarily a bad thing, as this water was all intramuscular so it just aids in the muscular fullness and made my muscle bellies look rounder, bigger, better, etc.

Because of this, I definitely wouldn’t hesitate to throw this into the “bulking SARM” category. Weight and strength gains were blatantly there even with no diet changes.

I noticed increased aggression, which to me I can channel in the gym, which is a good thing, as I’m pretty laid back normally.

I’m not sure that this would be a good compound for someone who already has anger issues though as this could exasperate it a bit. Kind of a double-edged sword depending on your personality type I suppose.

I ran RAD-140 for 8 weeks.

My goals are no longer so aligned with getting jacked out of my tree and huge, but they’re more so aligned with staying very lean, aesthetic and tight, while maintaining decent size, so I will probably save RAD-140 until I get the itch to gain some appreciable mass again.

For a classic off-season bulker, this SARM would definitely be a solid choice.

The most effective dose I felt was 20-30mg per day.

With the half-life being relatively long, I only had to dose RAD-140 once per day.

I just did it right when I woke up in the morning each day.

If I was going to use RAD-140 again, I would probably run it for 10-12 weeks.

Any less than that wouldn’t produce as much appreciable mass as could be attained using the SARM for a longer cycle length in my opinion.

Real off-season mass is built in long slow tapered bulks spanning over several months, not weeks.

To date there have been no reported side effects of RAD-140.

Whether it causes testosterone suppression to any degree like other SARMs can hasn’t been concluded, hence it is still probably safer to assume that RAD-140, like any other SARM, has a chance of slightly suppressing your endocrine system and would then require a PCT afterwards.

In addition, I personally noticed slightly increased aggression on it.

This is a common theme amongst users, as well as my personal friends who have also tried it.

Yes, if you are cutting in a calorie deficit RAD-140 will allow you to retain MUCH more lean muscle mass than you would otherwise at a caloric deficit, and in a calorie surplus RAD-140 will promote far greater lean muscle gains than you would otherwise gain.

The anabolic properties of RAD-140 make it ideal for any scenario you want to use it in.

RAD-140 also works very nicely in a body recomposition phase where you eat ever so slightly above your maintenance level of calories, and build some muscle while simultaneously burning some fat.

I never recommend recomposition phases though as they aren’t nearly as productive as a dedicated bulk, or a dedicated cut.

A sample cycle of a very productive bulk phase is outlined below:

Week 1-12: LGD-4033 10mg per day dosed once per day in the AM

Week 1-12: MK-677 25mg per day dosed once per day pre-bed

Week 1-12: RAD-140 20-30mg per day dosed once per day in the AM

Week 1-12: 1 Pill Arimi-RX PCT dosed once per day in the AM

(Mini-PCT) Week 13-16: 3 Pills Arimi-RX PCT dosed once per day in the AM

 

A sample cycle of a very productive cutting phase is outlined below:

Week 1-12: Ostarine/MK-2866 25mg per day dosed once per day in the AM

Week 1-12: RAD-140 20-30mg per day dosed once per day in the AM

Week 1-12: S4 50mg per day split into 2 doses per day…. 25mg in the AM and 25mg in the PM

Week 1-12: 1 Pill Arimi-RX PCT dosed once per day in the AM

(Mini-PCT) Week 13-16: 3 Pills Arimi-RX PCT dosed once per day in the AM

In the event that one experiences substantial testosterone suppression as a result of running a longer, higher dosed, or multiple SARM compound cycle, it is likely that delving into a PCT comprised of Nolvadex (Tamoxifen Citrate) and Clomid (Clomiphene Citrate) will be necessary instead.

Whenever I run a Nolvadex and Clomid PCT it typically breaks down as follows:

Week 1-4 (the four weeks immediately following my last SARM dose):

Week 1: Nolvadex – 40mg per day, Clomid – 50mg per day

Week 2: Nolvadex – 40mg per day, Clomid – 50mg per day

Week 3: Nolvadex – 20mg per day, Clomid – 25mg per day

Week 4: Nolvadex – 20mg per day, Clomid – 25mg per day

RAD-140 is a very versatile SARM that purportedly provides a complete replacement for testosterone replacement therapy (TRT), without any of the side effects.

Do I personally think that RAD-140 can completely fix you up if you have chronically low free test levels?

No I don’t, however I do believe that it can definitely replicate the effects and many of the benefits of testosterone, as well as produce substantial gains equivalent of that to a TRT dose of testosterone.

It can also potentiate the benefits of testosterone in a steroid cycle, while reducing its’ side effects.

As well as allow you to reduce your testosterone dose, while still achieving the same results as you would with a higher dose of testosterone simply by adding in RAD-140 instead of more exogenous testosterone.

It has a very long list of benefits, and it provides a unique level of versatility in any athlete’s pursuit of performance enhancement and quality of life.

If you have any questions, feel free to comment below or contact me.

This article is intended for educational/informational purposes only. This product is intended as a research chemical only.


Source: http://moreplatesmoredates.com/rad-140-testolone-overview/


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